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Home - Products - GPCR/G Protein - Neuropeptide Y Receptor - ML 154

ML 154

CAS No. 1345964-89-7

ML 154( NCGC84 )

Catalog No. M27660 CAS No. 1345964-89-7

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ML 154
  • Note
    Research use only, not for human use.
  • Brief Description
    ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
  • Description
    ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
  • In Vitro
    Western Blot Analysis Cell Line:CHO cells expressing NPSR Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM Incubation Time:30 min Result:Exhibited the most potent inhibition on NPS-induced ERK phosphorylation.
  • In Vivo
    Animal Model:Male Wistar rats (300-350 g) injected with alcohol Dosage:1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) Administration:Intraperitoneal injection; once Result:Inhibited alcohol-induced central ERK phosphorylation in vivo.
  • Synonyms
    NCGC84
  • Pathway
    GPCR/G Protein
  • Target
    Neuropeptide Y Receptor
  • Recptor
    G2019S LRRK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1345964-89-7
  • Formula Weight
    545.48
  • Molecular Formula
    C29H26BrN2PS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (114.58 mM)
  • SMILES
    [Br-].Cc1c([n+]2ccccc2n1C\C=C\c1ccccc1)P(=S)(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.
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